![]() Immunophenotyping using cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) provides high-resolution immune profiles, including new PD-L1/PD-L2 + macrophage populations associated with clinical outcome. We developed a single-cell method of intrinsic subtype classification (SCSubtype) to reveal recurrent neoplastic cell heterogeneity. Here we present a single-cell and spatially resolved transcriptomics analysis of human breast cancers. However, our knowledge of their cellular composition and organization is limited. cancers are complex cellular ecosystems where heterotypic interactions play central roles in disease progression and response to therapy. 27 St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
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